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I was Victor Frankenstein in a play once. This was in college. College for me consisted of studying, dating, and loads of humanties-related extracurricular activities, which meant I often had days at a time where I slept two or three hours a night. During Frankenstein I was in one of these no-sleep cycles, and was nearly dead on my feet. During one performance, I tried to bypass this little roadblock by taking three no-doz tablets (caffeine pills), in addition to the coffee that I was pretty much breathing. Then I forgot that I'd taken the no-doz and took three more.
I got a pretty heavy case of the shakes about halfway through the show, and was sweating a lot. My eyes were full-blown twitchy. On the positive side, this was around the scene where my passion and obsession over finishing the monster were at their peak, and I was alienating my friends and loved ones with frantic, single-minded nuttiness, so the shakes/sweats merely served to bolster my performance. The negative is that I spent intermission throwing up behind the theater.
Oh, and the original drawing for this piece IS for sale (you can see the uncolored scan on the original art sale page). It's $200 (that includes shipping). It's one of the most detailed things I've ever drawn, and we need a leaf-blower.